First Vial: And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image (Revelation 16:2). People who have received the mark of the Beast, the Antichrist, are afflicted with painful sores that are evidently incurable. Perhaps this is a universal reaction to receiving the mysterious mark of the Beast in the hand or the forehead -- some allergic affliction that falls upon all who have been imprinted with this satanic skin-credit-card that allows them to buy and sell during the Time of Jacob's Trouble.
Second Vial: And the second angel poured out his vial upon the sea; and it became as the blood of a dead man: and every living soul died in the sea (Revelation 16:3). The sea, once the source of food for man and his supposed hope for the future as a reservoir of nutrients, becomes as the blood of a dead man and every living thing in the sea dies.
Third Vial: And the third angel poured out his vial upon the rivers and fountains of waters; and they became blood (Revelation 16:4). The rivers and springs of the earth turn to blood as a judgment against the wicked Tribulation regime that has shed the blood of righteous people.
Fourth Vial: And the fourth angel poured out his vial upon the sun; and power was given unto him to scorch men with fire. And men were scorched with great heat, and blasphemed the name of God, which hath power over these plagues: and they repented not to give him glory (Revelation 16:8,9). The sun, which has befriended earth's citizens through the centuries, becomes their enemy, scorching men.
Fifth Vial: And the fifth angel poured out his vial upon the seat of the beast; and his kingdom was full of darkness; and they gnawed their tongues for pain, And blasphemed the God of heaven because of their pains and their sores, and repented not of their deeds (Revelation 16:10,11). Intense darkness comes upon the earth, accompanied by unbearable pain, causing ungodly people to blaspheme God. The Euphrates River is dried up and a huge army from the east marches through the dry riverbed on its way to Jerusalem.
Sixth Vial: And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared
(Revelation 16:12). Electrical storms and earthquakes that dwarf all such manifestations of nature in the past strike the earth with ferocity, destroying cities and causing nations to fall.
Seventh Vial: And the seventh angel poured out his vial into the air; and there came a great voice out of the temple of heaven, from the throne, saying, It is done. And there were voices, and thunders, and lightnings; and there was a great earthquake, such as was not since men were upon the earth, so mighty an earthquake, and so great. And the great city was divided into three parts, and the cities of the nations fell: and great Babylon came in remembrance before God, to give unto her the cup of the wine of the fierceness of his wrath. And every island fled away, and the mountains were not found. And there fell upon men a great hail out of heaven, every stone about the weight of a talent: and men blasphemed God because of the plague of the hail; for the plague thereof was exceeding great (Revelation 16:17-21).
The wrath of God is revealed from heaven against the Antichrist and his kingdom.